Takato Matsuda, Henry Wong, and Rika Nonaka are children who have, by fate, received real Digimon, unlike the imaginary ones in the card game they play. Each of the children, or "Digimon Tamers", has different views on how Digimon should be treated. But when other Digimon begin to appear around Japan, they must put aside their differences to fend off the digital intruders; even though Yamaki, who is the head of a secret organization called Hypnos is trying to eliminate all of the Digimon himself. Takato Matsuki was a regular fan of the Digimon card game. One fateful day, one of Takato's drawings slides in his Digi-vice. The result is that drawing coming to life. Two other kids, Henry Wong and Rika Nonaka, also receive their Digimon. Now, the unlikely trio must team up to defeat the Devas.
Takato Matsuda, Henry Wong dan Rika Nonaka ialah budak yang ditakdir menerima Digimon sebenar, bukan Digimon imaginasi yang dimain dengan kad. Mereka sebagai “Digimon Tamer” mempunyai pandangan yang berlainan untuk melayan Digimon. Tapi apabila Digimon lain mula muncul di seluruh Jepun, mereka mesti bersatu padu untuk menangkis penceroboh digital. Sementara itu, Yamaki, ketua bagi satu organisasi rahsia - Hypnos, juga cuba menghapus semua Digimon. Takato Matsuki ialah peminat kad permainan Digimon. Suatu hari Takato telah menghidupkan Digimon semasa mencabut kad dari Digi-vice secara kebetulan. Keadaan begini juga berlaku pada Henry Wong dan Rika Nonaka. Kini mereka bertiga mesti bergabung tenaga menewaskan Devas.