A samurai lord has bartered away his newborn son's organs to forty-eight demons in exchange for dominance on the battlefield. Yet, the abandoned infant survives thanks to a medicine man who equips him with primitive prosthetics—lethal ones with which the wronged son will use to hunt down the multitude of demons to reclaim his body one piece at a time, before confronting his father. On his journeys the young hero encounters an orphan who claims to be the greatest thief in Japan. 时为战乱年代。 醍醐之国的领主景光,在某所寺院的大堂中,向十二魔神像许愿让自己的领土繁荣。而诞生的景光之后嗣作为代价,身体各处都有所欠缺,被视作不祥之子而抛弃到河川之中。时光流逝,鬼神实现了与景光的约定,国家迎来了繁荣。这样的某天,名为“多罗罗”的年幼盗贼,与某个男人相遇。 那是鬼,还是人—— 两臂装有刀剑,全身皆为人造的男人“百鬼丸”,以他那无神光的双瞳紧紧盯着袭来的妖魔。